Dynein light intermediate chain binding
Web1 day ago · Additionally, to the HC, there are several light and intermediate chains present in the ODA and IDA, alongside with light-intermediate chains for the IDA. ... Step 2: The β-HC, from helical bundle 5 to the β-dynein head, shifts slightly. The two binding partners LC3 and the α kelch domain move with the β-tail. Step 3: The stalk and MTBD of ... WebMar 4, 2024 · The cytoplasmic dynein light intermediate chains (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood. Here, we used in …
Dynein light intermediate chain binding
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WebShop Target Dulles Store for furniture, electronics, clothing, groceries, home goods and more at prices you will love. WebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690-2701. DOI: 10.1091/mbc.e11-01-0075. ... The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National ...
WebJan 1, 2024 · The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc. Natl. Acad. Sci. U.S.A., 104 (2007), ... The … WebNov 23, 2024 · In future work it will be important to demonstrate that autoinhibition and its subsequent reversal by multivalent dynein light chain binding is a conserved process of IC among species and determine how this autoinhibition affects dynein function. ... (heavy chain), LIC (dynein light intermediate chain), N-IC (N-terminal domain of IC), C-IC, …
WebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing. WebJun 1, 2002 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: microtubule motor activity Source:UniProtKB. 1 publication. ... Consists of at least two heavy chains and a number of intermediate and light chains. Protein-protein interaction databases. BioGRID. 120722 7 interactors; IntAct. Q8TD57 6 …
Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components of the dynein motor complex, which includes the heavy chains (530 kDa), the light intermediate chains (52–61 kDa), the p150glued subunit of dynactin, and the light ...
WebAug 8, 2024 · An analysis of dynein-2 subunit interactions via a visible immunoprecipitation (VIP) assay has been published, demonstrating interactions between WDR60 and TCTEX1/3-TCTEX1D2; WDR34 and LC8 and Roadblock; and the intermediate chain-light chain complex with the heavy chain and light-intermediate chain . comment in fb not workingWebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … commenting a line in sublime textWebOct 1, 2014 · Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that … dry snitchedWebSpindly’s N-terminal coiled-coil uses distinct motifs to bind dynein light intermediate chain and the pointed-end complex of dynactin. Mutations in these motifs inhibit assembly of a dynein–dynactin–Spindly complex, and a null mutant of the dynactin pointed-end subunit p27 prevents kinetochore recruitment of dynein–dynactin without ... dry snitchesWebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major … comment in ftlWebCytoplasmic dynein is a member of the dynein superfamily of proteins. It is a massive multisubunit complex (1.2 MD) composed of two heavy chains (∼530 kD), three intermediate chains (74 kD), and four light intermediate chains (∼55 kD), and moves along microtubules toward their minus ends (13, 23) (Fig.5). commenting a block of code in pythonWebMar 29, 2024 · The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016] Other designations. … dry snake bite copperhead