Cisplatin with rt

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August undefined, 2024

WebJun 29, 2011 · Cisplatin is the most common agent used in combination with RT, and is one of the best studied. The standard regimen is three-weekly high-dose (100 mg/m 2) cisplatin (three cycles) concurrent with RT ( 2, 3 ). However, cisplatin at a dose of 100 mg/m 2 with concomitant RT is associated with significant acute and late toxicities ( 2, 4, … WebApr 12, 2024 · The patient was started on gemcitabine, cisplatin, and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). After 3 months of chemotherapy, the patient's AFP increased to 43.8 ng/ml and her CA 19-9 increased to 21.4 U/ml. On repeat CT scan, the size of the tumor was stable, but there was suspected intraductal extension toward the …

High-Dose Cisplatin for Head and Neck Cancer Lives On

WebWeekly cisplatin with radiotherapy for locally advanced head and neck squamous cell carcinoma. Our study shows that a median cumulative dose of 200 mg/m2 … WebRadiotherapy (RT) was given concurrently with cisplatin and etoposide. G-CSF was given as primary or secondary prophylaxis or as a therapeutic measure during an episode of febrile neutropenia according to local protocols. Common terminology criteria for adverse events (CTCAE) v3.0 was used to record toxicity. ... can hyperglycemia cause hypertension

Gemcitabine and daily radiotherapy for bladder preservation

WebCisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this … WebThe beneficial effects of cisplatin, which is the most widely used agent for CCRT in CC patients, whether alone or in combination with other drugs, were not independently reported in the CCCMAC study. 37 Our study focused on the comparisons between DDP-CCRT and exclusive RT to form a definitive conclusion for this issue. Moreover, only patients ... WebAug 29, 2012 · Cisplatin + RT for Triple Negative Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT01674842 Recruitment Status : … can hyperglycemia cause abdominal pain

Weekly cisplatin with radiotherapy for locally advanced head and …

Cisplatin + RT for Triple Negative Breast Cancer

Web1 day ago · Combined treatment with idronoxil and cisplatin enhances tumor response in humanized mice model. ... (Qiagen) according to the manufacturer's instructions. Total RNA (500 ng) was reversed transcribed with Primescript RT (Takara), with the cDNA serving as the template for amplification. Quantitative real-time PCR was subsequently performed … WebFeb 11, 2024 · Cisplatin was given either at a dose of 100 mg/m 2 every 3 weeks (day 1, 22, and 43) during RT (University Hospital Basel) to a planned cumulative dose of 300 mg/m 2 or at a dose of 40 mg/m 2 (University Hospital Zurich) or 50 mg/m 2 (Cantonal Hospital Winterthur) weekly for 6 or 7 infusions (days 1, 8, 15, 22, 29, 36, and 43) to a planned … fitnation group exercise scheduleWebThe beneficial effects of cisplatin, which is the most widely used agent for CCRT in CC patients, whether alone or in combination with other drugs, were not independently … can hyperglycemia cause shaking

"WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … " - Cisplatin with rt

Cisplatin with rt

Chemoradiotherapy with paclitaxel liposome plus cisplatin for …

WebJan 25, 2016 · Arm A represents concurrent pemetrexed-cisplatin (Pem-Cis) and thoracic radiation therapy (TRT) followed by consolidation pemetrexed. Arm B represents concurrent etoposide-cisplatin (Eto-Cis) and TRT followed by one of three consolidation chemotherapy regimens of choice: Eto-Cis, vinorelbine-cisplatin (Vin-Cis), or paclitaxel-carboplatin … WebFeb 16, 2016 · Cisplatin is standardly dosed in a three-weekly schedule of 100 mg/m 2 (total dose 300 mg/m 2) combined with standard RT [3,6,7,9,10]. However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity).

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WebOct 14, 2024 · Addition of concomitant cisplatin to RT improves outcome, with an absolute gain in overall survival (OS) of 6.5% at 5 years. 3 Cisplatin administered intravenously at a dose of 100 mg/m 2 every third week is … WebSep 21, 2016 · Cisplatin was discontinued for grade 3 or 4 peripheral neuropathy. During those weeks in which the patient did not receive CT, RT was continued as long as the WBC count was ≥ 2000/μL and the platelet count was ≥ 50,000/μL. RT was interrupted for a period of no greater than 1 week for grade 3 or 4 diarrhea.

WebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … WebMar 23, 2012 · The study showed that tri-weekly cisplatin 75 mg/m2 concurrent to RT is feasible and increase 5-year survival rate significantly compared to weekly cisplatin 40 mg/m2 in patients with locally advanced cervical cancer (66.5% in the weekly arm, 88.7% in the tri-weekly arm; HR=0.375, 95% CI: 0.154-0.914, p= .03).

WebSep 18, 2024 · NCBI Bookshelf WebJun 27, 2024 · Other Recommended Regimens. Capecitabine + Paclitaxel. (Category 2B) 22,23,a,b,h. Days 1-5: Capecitabine 625-825mg/m 2 orally twice daily. Day 1: Paclitaxel 45-50mg/m 2 IV over 1 hour. Repeat ...

WebDec 13, 2016 · This outcome is to confirm the safety and tolerability of escalating doses of BMX-001 in conjunction with RT and concurrent cisplatin in a cohort of newly diagnosed patients with locally advanced head and neck cancers. Each dose will be reported separately. Incidence Radiation-induced Mucositis by Clinician Scoring [ Time Frame: 6 …

WebApr 4, 2024 · First-line Combination Therapy for Recurrent, Unresectable, or Metastatic Disease (With No Surgery or RT Option) 1 Cisplatin or carboplatin + 5-FU + cetuximab … can hyperglycemia cause nausea and vomitingWebCisplatin + Fluorouracil 4-6,a,b Day 1: Cisplatin 50-75mg/m 2 IV over 60 minutes b Days 1-4: Fluorouracil 1000mg/m 2 IV continuous infusion over 24 hours daily. Repeat cycle every 3 week for 3-4 ... fitnation loginWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … fit nation gym instagramWebMar 26, 2024 · The use of two doses of high-dose cisplatin concurrently with accelerated RT has been shown to be as effective as three doses with standard-fractionation RT and is an acceptable treatment alternative for patients with HPV-OPC, resulting in a 33% decrease in cumulative cisplatin dose. 57, 59 Decreasing the dose of cisplatin as part of … can hyperglycemia be fatalWebSep 29, 2015 · High-dose cisplatin (CDDP)-based chemoradiotherapy (CRT) has significantly improved overall survival (OS), progression-free survival (PFS) and locoregional control compared with that observed with radiotherapy (RT) alone in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN) ( 1 ). can hyperglycemia cause shortness of breathWebOct 27, 2024 · The efficacy of the GD regimen may facilitate wider adoption of bladder preservation as many patients have comorbidities that preclude the use of cisplatin. The daily radiation schedule is also easier for patients and treatment centres to administer than twice daily treatment which will also likely increase interest in this strategy. fitnation echelonWebJun 29, 2011 · Cisplatin is the most common agent used in combination with RT, and is one of the best studied. The standard regimen is three-weekly high-dose (100 mg/m 2) … can hyperglycemia cause sleepiness