Breast cancer resistance protein 意味
WebP-glycoprotein. P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is a cell membrane protein that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with ... Web1 day ago · The research could lead to new therapies that have fewer side effects and work against cancers that have grown resistant to existing treatments. About 250,000 women …
Breast cancer resistance protein 意味
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WebMar 5, 2024 · Introduction. Multidrug resistance (MDR) accounts for chemotherapeutic resistance in cancer cells ().Three major proteins namely P-glycoprotein (P-gp, also referred to as MDR1), MDR … WebJun 1, 2024 · Breast cancer resistance protein (BCRP) is expressed on the apical membrane of small intestinal epithelial cells and functions as an efflux pump with broad substrate recognition. Therefore, quantitative evaluation of the contribution of BCRP to the intestinal permeability of new chemical entities is very important in drug research and …
WebWikipedia WebBreast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene …
WebMar 3, 2024 · 因此，对多药耐药（multidrug resistance，MDR）机制的研究仍是当今肿瘤研究领域的一个热点。 ... glycoprotein，P-gp）、MDR 相关蛋白（multidrugresistanceassociated protein，MRP）、乳腺癌耐药蛋白（breast cancer resistance protein，BCRP）等。 ... 的敏感性下降，从而产生耐药；二是 ... Web4 hours ago · CU Boulder researchers have discovered a protein’s crucial role in helping breast and ovarian tumors survive and thrive and have found that suppressing that …
WebSep 1, 2004 · Gefitinib inhibits the transporter function of BCRP and reverses B CRP-mediated drug resistance both in vitro and in vivo, and suggests that gefit inib may overcome BCRp- mediated drug resistance by inhibiting the pump function ofBCRP. Breast cancer resistance protein (BCRP) is an ATP binding cassette transporter that confers …
This protein is a member of the White subfamily. Alternatively referred to as the breast cancer resistance protein (BCRP), this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. See more ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation … See more It is inhibited by some calcium channel blockers such as amlodipine, felodipine and nifedipine. The fungal toxin fumitremorgin C (FTC) inhibits the protein but has neurotoxic side … See more • ABCG2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human ABCG2 genome location and ABCG2 gene details page in the See more The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The active transport of chemicals … See more • ATP-binding cassette transporter See more • Hazai E, Bikádi Z (April 2008). "Homology modeling of breast cancer resistance protein (ABCG2)". Journal of Structural Biology. 162 (1): 63–74. doi: • Abbott BL (January 2006). … See more diverse schools in washingtonWebThe most well known genes associated with increased breast cancer risk are BRCA1 and BRCA2. Women with abnormal BRCA1 or BRCA2 experience up to a 60% risk to … diverse securityWeb直至2010年，针对免疫检查点的抗体——抗细胞毒性T细胞相关抗原(cytotoxic T-lymphocyte-associated antigen,CTLA)-4单抗和抗程序性细胞死亡蛋白(programmed death protein,PD)-1单抗成功治疗进展期黑色素瘤，以及表达嵌合抗原受体的自体T细胞疗法(CAR-T)成功治疗白血病和淋巴瘤以后 ... diverse sectorenWebApr 1, 2002 · Abstract. Purpose: The breast cancer resistance protein (BCRP) is involved in in vitro multidrug resistance and was first identified in the breast cancer cell line … cracked typing master 11WebApr 11, 2024 · 251.Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome. 过多的核糖体蛋白生产使脆性X综合征模型中的翻译失衡。 252.Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer. cracked typing masterWeb1 day ago · Scientists at VCU Massey Cancer Center discovered that the deletion of a specific protein creates a hostile environment for tumor cells and significantly subdues … cracked typing master 10WebApr 14, 2024 · When it comes to endocrine resistance, estrogen withdrawal can activate UPR (unfolded protein response) , leading to the release of glucose-regulated protein … diverse sectors